Pitchfork regulates primary cilia disassembly
نویسندگان
چکیده
منابع مشابه
DISC1 Regulates Primary Cilia That Display Specific Dopamine Receptors
BACKGROUND Mutations in the DISC1 gene are strongly associated with major psychiatric syndromes such as schizophrenia. DISC1 encodes a cytoplasmic protein with many potential interaction partners, but its cellular functions remain poorly understood. We identified a role of DISC1 in the cell biology of primary cilia that display disease-relevant dopamine receptors. METHODOLOGY/PRINCIPAL FINDIN...
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Non-motile primary cilium is an antenna-like structure whose defect is associated with a wide range of pathologies, including developmental disorders and cancer. Although mechanisms regulating cilia assembly have been extensively studied, how cilia disassembly is regulated remains poorly understood. Here, we report unexpected roles of Dishevelled 2 (Dvl2) and interphase polo-like kinase 1 (Plk1...
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Kyung Ho Lee, Yoshikazu Johmura, Li-Rong Yu, Jung-Eun Park, Yuan Gao, Jeong K Bang, Ming Zhou, Timothy D Veenstra, Bo Yeon Kim and Kyung S Lee* Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA, Division of Systems Biology, Center for Proteomics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA, Divi...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2009
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2009.05.557